Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stress.

The Journal of biological chemistry - 4 Jul 2003

Wang Xiaosong, Phelan Shelley A, Forsman-Semb Kristina, Taylor Eric F, Petros Christina, Brown Aaron, Lerner Charles P, Paigen Beverly

Abstract excerpt

Reactive oxygen species, especially hydrogen peroxide, are important in cellular signal transduction. However, excessive amounts of these species damage tissues and cells by oxidizing virtually all important biomolecules. Peroxiredoxin 6 (PRDX6) (also called antioxidant protein 2, or AOP2) is a novel peroxiredoxin family member whose function in vivo is unknown. Through immunohistochemistry, we have determined...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryonic and Fetal Development
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Oxidative Stress

Share to Peroxidases

Share to Peroxiredoxins

Source

Identifiers

PMID: 12732627
DOI: 10.1074/jbc.M302706200

Genes

PRDX6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stress.PMID 12732627Read ↗

Targeted disruption of peroxiredoxin 6 gene renders the heart vulnerable to ischemia-reperfusion injury.Semantic proximity Read ↗

Impaired homeostasis and phenotypic abnormalities in Prdx6-/-mice lens epithelial cells by reactive oxygen species: increased expression and activation of TGFbeta.Semantic proximity Read ↗

Protein expression profiling of lens epithelial cells from Prdx6-depleted mice and their vulnerability to UV radiation exposure.Semantic proximity Read ↗

Peroxiredoxin 4 (PRDX4): Its Critical <em>In Vivo</em> Roles in Animal Models of Metabolic Syndrome Using Our Unique PRDX4 Transgenic MiceSemantic proximity Read ↗

PRDX4, an endoplasmic reticulum-localized peroxiredoxin at the crossroads between enzymatic oxidative protein folding and nonenzymatic protein oxidation.Semantic proximity Read ↗

Peroxiredoxin 6 deficiency and atherosclerosis susceptibility in mice: significance of genetic background for assessing atherosclerosis.Semantic proximity Read ↗

Tissue-Specific Profiling of Oxidative Stress-Associated Transcriptome in a Healthy Mouse ModelSemantic proximity Read ↗

Peroxiredoxin1, a novel regulator of pronephros development, influences retinoic acid and Wnt signaling by controlling ROS levels.Semantic proximity Read ↗

Peroxiredoxin 5 confers protection against oxidative stress and apoptosis and also promotes longevity in Drosophila.Semantic proximity Read ↗

Double edged roles of endogenous PRDX6 in ventilator-induced lung injury via modulating oxidative stress and macrophages activationSemantic proximity Read ↗

Overexpression of Prdx6 reduces H2O2 but does not prevent diet-induced atherosclerosis in the aortic root.Semantic proximity Read ↗

The <i>Peroxiredoxin 6</i> gene plays a critical role in the homeostatic regulation of fear responseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.