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Article

Differential cell death decisions in the testis: evidence for an exclusive window of ferroptosis in round spermatids

4 Mar 2019

Abstract excerpt

Oxidative stress is a major aetiology in many pathologies, including that of male infertility. Recent evidence in somatic cells has linked oxidative stress to the induction of a novel cell death modality termed ferroptosis. However, the induction of this iron-regulated, caspase-independent cell death pathway has never been explored outside of the soma. Ferroptosis is initiated through the inactivation of the...

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PMID: 30865280
DOI: 10.1093/molehr/gaz015

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