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Article

Peroxiredoxin 5 Decreases Beta-Amyloid-Mediated Cyclin-Dependent Kinase 5 Activation Through Regulation of Ca2+-Mediated Calpain Activation.

Antioxidants & redox signaling - 10 Oct 2017

Park Junghyung, Kim Bokyung, Chae Unbin, Lee Dong Gil, Kam Min Kyoung, Lee Sang-Rae, Lee Seunghoon, Lee Hyun-Shik, Park Jeen-Woo, Lee Dong-Seok

Abstract excerpt

AIMS: Aberrant Cdk5 (cyclin-dependent kinase 5) and oxidative stress are crucial components of diverse neurodegenerative disorders, including Alzheimer's disease (AD). We previously reported that a change in peroxiredoxin (Prx) expression is associated with protection from neuronal death. The aim of the current study was to analyze the role of Prx in regulating Cdk5 activation in AD. RESULTS: We found that of the...

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PMID: 28358580
DOI: 10.1089/ars.2016.6810

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APP

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