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Article

Lack of alpha 1b-adrenergic receptor protects against epileptic seizures.

Epilepsia - 1 Jan 2009

Pizzanelli Chiara, Lazzeri Gloria, Fulceri Federica, Giorgi Filippo S, Pasquali Livia, Cifelli Giuseppe, Murri Luigi, Fornai Francesco

Abstract excerpt

PURPOSE: The role of alpha 1b-adrenergic receptor (alpha 1b-AR) in relation with neuronal degeneration, drug addiction, and seizure susceptibility has recently emerged. In particular, mice that overexpress alpha 1b-AR undergo spontaneous epileptic seizures and progressive neuronal loss in a variety of brain areas. Therefore, one should expect that the blockade of alpha 1b-AR leads to anticonvulsant and...

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PMID: 19125850
DOI: 10.1111/j.1528-1167.2008.01972.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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