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Article

Development of a floxed Gabbr2 gene allows for widespread conditional disruption of GABBR2 and recapitulates the phenotype of germline Gabbr2 knockout mice.

PloS one - 1 Jan 2025

Hens Julie Rose, Brown Stacey, Licznerski Pawel, Suarez Jacqueline, Jonas Elizabeth, Wysolmerski John J

Abstract excerpt

GABBR1 and GABBR2 are widely expressed in the brain and genetic inhibition of their function leads to neurologic dysfunction and premature death in mice. Given that GABBR1 and GABBR2 heterodimerize to form a functional receptor, global knockout of GABBR1 or GABBR2 results in a similar phenotype, characterized by spontaneous epileptiform activity, hyperlocomotor activity, hyperalgesia, impaired memory and...

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Identifiers

PMID: 41397015
DOI: 10.1371/journal.pone.0318760
PMCID: PMC12704887

Genes

GABBR2
GABBR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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