Article
PTEN polymorphisms and the risk of esophageal carcinoma and gastric cardiac carcinoma in a high incidence region of China.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus - 1 Jan 2008
Ge H, Cao Y Y, Chen L Q, Wang Y M, Chen Z F, Wen D G, Zhang X F, Guo W, Wang N, Li Y, Zhang J H
Abstract excerpt
PTEN, as a tumor suppressor gene, plays an important role in regulating cell growth, proliferation, and apoptosis. Two common polymorphisms, -9C/G and IVS4 (-/+), may alter susceptibility to the disease. To test the hypothesis that the genetic variations of PTEN play a role in the etiology of esophageal squamous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA), a population-based case-control study...
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