Article
High-incidence of PTEN mutations in Chinese patients with primary small cell carcinoma of the esophagus.
BMC cancer - 14 Jan 2014
Zhang Zhimin, Xiao Hualiang, Xie Fei, Zhang Hui, Chen Chuan, Xiao He, Yang Zhenzhou, Wang Dong, Li Zengpeng, Wang Ge
Abstract excerpt
BACKGROUND: Primary small cell carcinoma of the esophagus (PSCCE) is a rare and aggressive tumor with poor prognosis. The aim of this study was to investigate the existence of EGFR, KRAS, PIK3CA and PTEN mutations in PSCCE. METHODS: Clinical-pathological data and paraffin-embedded specimens were collected from 38 patients. Exons 18 to 21 of EGFR, KRAS and PIK3CA status were analyzed by real-time PCR based on ARMS...
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