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Article

Next-generation Sequencing Reveals Recurrent Somatic Mutations in Small Cell Neuroendocrine Carcinoma of the Uterine Cervix.

The American journal of surgical pathology - 1 Jun 2018

Xing Deyin, Zheng Gang, Schoolmeester John Kenneth, Li Zaibo, Pallavajjala Aparna, Haley Lisa, Conner Michael G, Vang Russell, Hung Chien-Fu, Wu Tzyy-Choou, Ronnett Brigitte M

Abstract excerpt

Small cell neuroendocrine carcinoma (SCNEC) of the uterine cervix is a rare but extremely aggressive tumor. While high-risk human papillomavirus (HPV) is involved at an early stage of oncogenesis in many tumors, additional driving events have been postulated to facilitate the progression of SCNECs. Identification of oncogenic drivers could guide targeted therapy of this neoplasm. Clinicopathologic features of 10...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29505425
DOI: 10.1097/PAS.0000000000001042
PMCID: PMC5943084

Genes

BCL6
BRCA1
BRCA2
KRAS
NCOA3
NOTCH1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Next-generation Sequencing Reveals Recurrent Somatic Mutations in Small Cell Neuroendocrine Carcinoma of the Uterine Cervix.PMID 29505425Read ↗

The next generation sequencing of cancer-related genes in small cell neuroendocrine carcinoma of the cervixSemantic proximity Read ↗

Morphologic and Molecular Heterogeneity of Cervical Neuroendocrine NeoplasiaSemantic proximity Read ↗

Whole exome sequencing identifies common mutational landscape of cervix and endometrium small cell neuroendocrine carcinomaSemantic proximity Read ↗

Human Papilloma Virus 18-Positive Submucosal Small Cell Neuroendocrine Carcinoma of the Vagina: An Immunohistochemical and Genomic Study.Semantic proximity Read ↗

Comparative genomics of high grade neuroendocrine carcinoma of the cervix.Semantic proximity Read ↗

Cervical small cell neuroendocrine tumor mutation profiles via whole exome sequencing.Semantic proximity Read ↗

Sequencing of mutational hotspots in cancer-related genes in small cell neuroendocrine cervical cancer.Semantic proximity Read ↗

Single‐Cell RNA Sequencing Reveals the Cellular Origin and Evolution of Small‐Cell Neuroendocrine Carcinoma of the CervixSemantic proximity Read ↗

Single-cell RNA sequencing reveals tumor heterogeneity in small cell neuroendocrine cervical carcinomaSemantic proximity Read ↗

Genomic characterization of small cell carcinomas of the uterine cervix.Semantic proximity Read ↗

Single-Cell Transcriptome Sequencing and Analysis Provide a New Approach for the Treatment of Small Cell Neuroendocrine Carcinoma of the CervixSemantic proximity Read ↗

Unique Genomic Landscape of High-Grade Neuroendocrine Cervical Carcinoma: Implications for Rethinking Current Treatment ParadigmsSemantic proximity Read ↗

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