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Urothelial Cancers with Small Cell Variant Histology Have Confirmed High Tumor Mutational Burden, Frequent TP53 and RB Mutations, and a Unique Gene Expression Profile.

European urology oncology - 1 Apr 2021

Hoffman-Censits Jean, Choi Woonyoung, Pal Sumanta, Trabulsi Edouard, Kelly William Kevin, Hahn Noah M, McConkey David, Comperat Eva, Matoso Andres, Cussenot Oliver, Cancel-Tassin Geraldine, Fong Megan Hoi Yan, Ross Jeffrey, Madison Russell, Ali Siraj

Abstract excerpt

Although predominantly urothelial, some bladder cancer and upper tract urothelial cancer (BC/UTUC) harbor histologic variants. Small cell BC (SCBC) variants comprised ˜5% of The Cancer Genome Atlas BC cohort, with a poor prognosis. We describe genomic profiles of BC/UTUC with small cell/neuroendocrine features identified in the Foundation Medicine database from June 2012 to September 2018. Of 3368 BC/UTUC...

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PMID: 32061548
DOI: 10.1016/j.euo.2019.12.002

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