Small-Cell Carcinomas of the Bladder and Lung Are Characterized by a Convergent but Distinct Pathogenesis.

doi:10.1158/1078-0432.CCR-17-2655

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Article

Small-Cell Carcinomas of the Bladder and Lung Are Characterized by a Convergent but Distinct Pathogenesis.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2018

Chang Matthew T, Penson Alexander, Desai Neil B, Socci Nicholas D, Shen Ronglai, Seshan Venkatraman E, Kundra Ritika, Abeshouse Adam, Viale Agnes, Cha Eugene K, Hao Xueli, Reuter Victor E, Rudin Charles M, Bochner Bernard H, Rosenberg Jonathan E, Bajorin Dean F, Schultz Nikolaus, Berger Michael F, Iyer Gopa, Solit David B, Al-Ahmadie Hikmat A, Taylor Barry S

Abstract excerpt

Purpose: Small-cell carcinoma of the bladder (SCCB) is a rare and aggressive neuroendocrine tumor with a dismal prognosis and limited treatment options. As SCCB is histologically indistinguishable from small-cell lung cancer, a shared pathogenesis and cell of origin has been proposed. The aim of this study is to determine whether SCCBs arise from a preexisting urothelial carcinoma or share a molecular...

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PMID: 29180607
DOI: 10.1158/1078-0432.CCR-17-2655
PMCID: PMC5965261

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