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Article

Emergence and evolution of enfuvirtide resistance following long-term therapy involves heptad repeat 2 mutations within gp41.

Antimicrobial agents and chemotherapy - 1 Mar 2005

Xu L, Pozniak A, Wildfire A, Stanfield-Oakley S A, Mosier S M, Ratcliffe D, Workman J, Joall A, Myers R, Smit E, Cane P A, Greenberg M L, Pillay D

Abstract excerpt

The objective of this study was to track the evolution of sequence changes in both the heptad region 1 (HR1) and HR2 domains of gp41 associated with resistance to enfuvirtide (ENF) in a patient cohort receiving long-term ENF treatment. We studied 17 highly antiretroviral agent-experienced patients receiving long-term ENF treatment with virological rebound or a lack of suppression. Sixty-two samples obtained after...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15728911
DOI: 10.1128/AAC.49.3.1113-1119.2005
PMCID: PMC549241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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