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Article

Mutations conferring resistance to human immunodeficiency virus type 1 fusion inhibitors are restricted by gp41 and Rev-responsive element functions.

Journal of virology - 1 Jan 2005

Nameki Daisuke, Kodama Eiichi, Ikeuchi Mieko, Mabuchi Naoto, Otaka Akira, Tamamura Hirokazu, Ohno Mutsuhito, Fujii Nobutaka, Matsuoka Masao

Abstract excerpt

One of the human immunodeficiency virus (HIV) envelope proteins, gp41, plays a key role in HIV fusion. A gp41-derived peptide, T-20, efficiently inhibits HIV fusion and is currently approved for treatment of HIV-infected individuals. Although resistant variants have been reported, the mechanism of the resistance remains to be defined. To elucidate the mechanism in detail, we generated variants resistant to C34, a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15613304
DOI: 10.1128/JVI.79.2.764-770.2005
PMCID: PMC538534

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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