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Article

ALDH2---The Genetic Polymorphism and Enzymatic Activity Regulation: Their Epidemiologic and Clinical Implications.

Current drug targets - 1 Jan 2017

Zhang Rui, Wang Jiali, Xue Mengyang, Xu Feng, Chen Yuguo

Abstract excerpt

BACKGROUND: The human aldehyde dehydrogenase 2 (ALDH2) is the most effective enzyme in the detoxification of alcohol metabolite acetaldehyde. The ALDH2*2 mutation is caused by a single nucleotide substitution which results in a nearly inactive form of ALDH2 enzyme. The ALDH2 genotype has been used as a surrogate of alcohol to get causal inferences of alcohol in related diseases implementing Mendelian...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 26212265
DOI: 10.2174/1389450116666150727115118

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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