Article
Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review.
American journal of epidemiology - 1 Jan 2004
Brennan Paul, Lewis Sarah, Hashibe Mia, Bell Douglas A, Boffetta Paolo, Bouchardy Christine, Caporaso Neil, Chen Chu, Coutelle Christiane, Diehl Scott R, Hayes Richard B, Olshan Andrew F, Schwartz Stephen M, Sturgis Erich M, Wei Qingyi, Zavras Athanasios I, Benhamou Simone
Abstract excerpt
Possession of the fast metabolizing alleles for alcohol dehydrogenase (ADH), ADH1B*2 and ADH1C*1, and the null allele for aldehyde dehydrogenase (ALDH), ALDH2*2, results in increased acetylaldehyde levels and is hypothesized to increase the risk of head and neck cancer. To examine this association, the authors undertook a Human Genome Epidemiology review on these three genes and a pooled analysis of published...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.