Smoking and alcohol by HPV status in head and neck cancer: a Mendelian randomization study.

doi:10.1038/s41467-024-51679-x

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Article

Smoking and alcohol by HPV status in head and neck cancer: a Mendelian randomization study.

Nature communications - 7 Sept 2024

Thakral Abhinav, Lee John Jw, Hou Tianzhichao, Hueniken Katrina, Dudding Tom, Gormley Mark, Virani Shama, Olshan Andrew, Diergaarde Brenda, Ness Andrew R, Waterboer Tim, Smith-Byrne Karl, Brennan Paul, Hayes D Neil, Sanderson Eleanor, Brown M Catherine, Huang Sophie, Bratman Scott V, Spreafico Anna, De Almeida John, Davies Joel C, Bierut Laura, Macfarlane Gary J, Lagiou Pagona, Lagiou Areti, Polesel Jerry, Agudo Antonio, Alemany Laia, Ahrens Wolfgang, Healy Claire M, Conway David I, Nygard Mari, Canova Cristina, Holcatova Ivana, Richiardi Lorenzo, Znaor Ariana, Goldstein David P, Hung Rayjean J, Xu Wei, Liu Geoffrey, Espin-Garcia Osvaldo

Abstract excerpt

HPV-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) are recognized as distinct entities. There remains uncertainty surrounding the causal effects of smoking and alcohol on the development of these two cancer types. Here we perform multivariable Mendelian randomization (MR) to evaluate the causal effects of smoking and alcohol on the risk of HPV-positive and HPV-negative HNSCC in 3431 cases...

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Identifiers

PMID: 39244563
DOI: 10.1038/s41467-024-51679-x
PMCID: PMC11380676

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