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TGF-β Signaling in Development

14 Aug 2007

Abstract excerpt

The transforming growth factor-beta (TGF-beta) superfamily comprises nearly 30 growth and differentiation factors that include TGF-betas, activins, inhibins, and bone morphogenetic proteins (BMPs). Multiple members of the TGF-beta superfamily serve key roles in stem cell fate commitment. The various members of the family can exhibit disparate roles in regulating the biology of embryonic stem (ES) cells and tumor...

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PMID: 17699101
DOI: 10.1126/stke.3992007cm1

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