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Article

BCL2 protein expression in follicular lymphomas with t(14;18) chromosomal translocations.

British journal of haematology - 1 Mar 2009

Masir Noraidah, Campbell Lisa J, Goff Lindsey K, Jones Margaret, Marafioti Teresa, Cordell Jacqueline, Clear Andrew J, Lister T Andrew, Mason David Y, Lee Abigail M

Abstract excerpt

The t(14;18)(q32;q21) chromosomal translocation induces BCL2 protein overexpression in most follicular lymphomas. However the expression of BCL2 is not always homogeneous and may demonstrate a variable degree of heterogeneity. This study analysed BCL2 protein expression pattern in 33 cases of t(14;18)-positive follicular lymphomas using antibodies against two different epitopes (i.e. the widely used antibody...

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Share to Chromosomes, Human, Pair 14
Share to Chromosomes, Human, Pair 18

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, bcl-2

Share to In Situ Hybridization, Fluorescence

Share to Ki-67 Antigen

Share to Lymphoma, Follicular

Share to Proto-Oncogene Proteins c-bcl-2

Share to Translocation, Genetic

Source

Identifiers

PMID: 19120369
DOI: 10.1111/j.1365-2141.2008.07528.x

Genes

BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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BCL2 protein expression in follicular lymphomas with t(14;18) chromosomal translocations.PMID 19120369Read ↗

Lack of Bcl-2 expression in follicular lymphoma may be caused by mutations in the BCL2 gene or by absence of the t(14;18) translocation.Semantic proximity Read ↗

Follicular lymphoma lacking the t(14;18)(q32;q21): identification of two disease subtypesSemantic proximity Read ↗

Partial lack of BCL2 in follicular lymphoma: An unusual immunohistochemical staining pattern explained by ongoing BCL2 mutation.Semantic proximity Read ↗

Follicular lymphomas with and without translocation t(14;18) differ in gene expression profiles and genetic alterations.Semantic proximity Read ↗

Low-grade follicular lymphoma with t(14;18) presents a homogeneous disease entity otherwise the rest comprises minor groups of heterogeneous disease entities with Bcl2 amplification, Bcl6 translocation or other gene aberrances.Semantic proximity Read ↗

BCL2 gene abnormalities define distinct clinical subsets of follicular lymphomaSemantic proximity Read ↗

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BCL6-translocations affect the phenotype of follicular lymphomas only in the absence of t(14;18)IgH/BCL2.Semantic proximity Read ↗

Practical Detection of t(14;18)(IgH/BCL2) in Follicular LymphomaSemantic proximity Read ↗

Causes and Consequences ofBCL2Overexpression in Diffuse Large B-Cell LymphomaSemantic proximity Read ↗

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