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Article

Lack of Bcl-2 expression in follicular lymphoma may be caused by mutations in the BCL2 gene or by absence of the t(14;18) translocation.

The Journal of pathology - 1 Feb 2005

Schraders Margit, de Jong Daphne, Kluin Philip, Groenen Patricia, van Krieken Han

Abstract excerpt

Follicular lymphoma (FL), except grade 3B, is characterized by the chromosomal translocation t(14;18)(q32;q21), which results in over-expression of the Bcl-2 protein. Ten per-cent of all FLs, however, do not show Bcl-2 protein expression with standard immunohistochemistry using a monoclonal Bcl-2 antibody against residues 41-54 of the Bcl-2 protein. In this study, the biological background of 18 Bcl-2-negative FL...

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Share to Chromosomes, Human, Pair 14
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Share to Genes, bcl-2

Share to In Situ Hybridization, Fluorescence

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Source

Identifiers

PMID: 15682435
DOI: 10.1002/path.1689

Genes

BCL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lack of Bcl-2 expression in follicular lymphoma may be caused by mutations in the BCL2 gene or by absence of the t(14;18) translocation.PMID 15682435Read ↗

BCL2 protein expression in follicular lymphomas with t(14;18) chromosomal translocations.Semantic proximity Read ↗

Follicular lymphoma lacking the t(14;18)(q32;q21): identification of two disease subtypesSemantic proximity Read ↗

Partial lack of BCL2 in follicular lymphoma: An unusual immunohistochemical staining pattern explained by ongoing BCL2 mutation.Semantic proximity Read ↗

BCL2 gene abnormalities define distinct clinical subsets of follicular lymphomaSemantic proximity Read ↗

Follicular lymphomas with and without translocation t(14;18) differ in gene expression profiles and genetic alterations.Semantic proximity Read ↗

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BCL6-translocations affect the phenotype of follicular lymphomas only in the absence of t(14;18)IgH/BCL2.Semantic proximity Read ↗

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