Article
The role of Toll-like receptors 3 and 9 in the development of autoimmune diabetes in NOD mice.
Annals of the New York Academy of Sciences - 1 Dec 2008
Wong F Susan, Hu Changyun, Zhang Li, Du Wei, Alexopoulou Lena, Flavell Richard A, Wen Li
Abstract excerpt
Innate immunity is mediated, at least in part, through a number of receptors known as Toll-like receptors (TLRs), which are activated by different microbial stimuli. Adaptive immunity, including autoimmunity, follows the innate response in a more specific manner. To investigate the roles of TLR3 and TLR9 in the development of type 1 diabetes, we generated NOD mice that are deficient in TLR3 and 9, respectively....
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