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Article

Determination of the real effect of genes identified in GWAS: the example of IL2RA in multiple sclerosis.

European journal of human genetics : EJHG - 1 Mar 2012

Babron Marie-Claude, Perdry Hervé, Handel Adam E, Ramagopalan Sreeram V, Damotte Vincent, Fontaine Bertrand, Müller-Myhsok Bertram, Ebers George C, Clerget-Darpoux Françoise

Abstract excerpt

Genome-wide association studies (GWAS), although efficient to detect genes involved in complex diseases, are not designed to measure the real effect of the genes. This is illustrated here by the example of IL2RA in multiple sclerosis (MS). Association between IL2RA and MS is clearly established, although the functional variation is still unknown: the effect of IL2RA might be better described by several SNPs than...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Interleukin-2 Receptor alpha Subunit

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Identifiers

PMID: 22085902
DOI: 10.1038/ejhg.2011.197
PMCID: PMC3283173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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