Article
Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity.
American journal of human genetics - 1 Mar 2000
Scott W K, Grubber J M, Conneally P M, Small G W, Hulette C M, Rosenberg C K, Saunders A M, Roses A D, Haines J L, Pericak-Vance M A
Abstract excerpt
Apolipoprotein E (APOE) is the only confirmed susceptibility gene for late-onset Alzheimer disease (AD). In a recent genomic screen of 54 families with late-onset AD, we detected significant evidence for a second late-onset AD locus located on chromosome 12 between D12S373 and D12S390. Linkage to this region was strongest in 27 large families with at least one affected individual without an APOE-4 allele,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.