Fibrocontractive Müller cell phenotypes in proliferative diabetic retinopathy.

doi:10.1167/iovs.08-2475

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Article

Fibrocontractive Müller cell phenotypes in proliferative diabetic retinopathy.

Investigative ophthalmology & visual science - 1 Apr 2009

Guidry Clyde, King Jeffery L, Mason John O

Abstract excerpt

PURPOSE: To evaluate Müller cells as a potential source of fibrocontractive cells in proliferative diabetic retinopathy. METHODS: Temporal changes in glial fibrillary acidic protein (GFAP), vimentin, glutamine synthetase, and alpha smooth muscle actin (alphaSMA) expression in cultures of freshly isolated porcine Müller cells were evaluated by indirect immunofluorescence and Western blotting. A similar evaluation...

Topics

Actins
Animals
Blotting, Western
Cell Separation
Cells, Cultured
Diabetic Retinopathy
Epiretinal Membrane
Fibroblasts
Fluorescent Antibody Technique, Indirect
Glial Fibrillary Acidic Protein
Glucose
Glutamate-Ammonia Ligase
Microscopy, Fluorescence
Neuroglia
Phenotype
Swine
Vimentin

Source

Open in PubMed

Identifiers

PMID: 19117921
DOI: 10.1167/iovs.08-2475

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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