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Regional Alterations in Müller Cell Protein Expression in Human and a Rat Model of Geographic Atrophy

7 Feb 2025

Abstract excerpt

Purpose: Despite being crucial to neuronal survival, the role Müller cells play in geographic atrophy (GA) has only recently been considered. We investigated whether Müller cells retain their normal functional profile or form a fibrotic scar when remodeling in human GA eyes and our subretinal sodium iodate (NaIO3) model. Methods: Sprague Dawley rats given subretinal injections of NaIO3 (5 mg/mL) were sacrificed...

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PMID: 39918478
DOI: 10.1167/iovs.66.2.21

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