Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Plasminogen activator inhibitor variants PAI-1 A15T and PAI-2 S413C influence lung cancer prognosis.

Lung cancer (Amsterdam, Netherlands) - 1 Aug 2009

Di Bernardo Maria Chiara, Matakidou Athena, Eisen Tim, Houlston Richard S

Abstract excerpt

The plasminogen pathway plays an important role in the behavior of many tumors including lung cancer. Hence genetic variants encoding plasminogen activator (PLAU), plasminogen receptor (PLAUR), plasminogen activator inhibitor 1 (PAI-1) and plasminogen activator inhibitor 2 (PAI-2) may contribute to lung cancer prognosis. To investigate this proposition we genotyped PAI-1 A15T, PLAU L141P, PLAUR L317P and PAI-2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Non-Small-Cell Lung
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kaplan-Meier Estimate

Share to Neoplasm Staging

Share to Plasminogen Activator Inhibitor 1

Share to Plasminogen Activators

Share to Receptors, Urokinase Plasminogen Activator

Share to Small Cell Lung Carcinoma

Source

Identifiers

PMID: 19117638
DOI: 10.1016/j.lungcan.2008.11.012

Genes

PLAU
PLAUR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plasminogen activator inhibitor variants PAI-1 A15T and PAI-2 S413C influence lung cancer prognosis.PMID 19117638Read ↗

The impact of polymorphic variations in the 5p15, 6p12, 6p21 and 15q25 Loci on the risk and prognosis of portuguese patients with non-small cell lung cancer.Semantic proximity Read ↗

Genetic variants in the human leukocyte antigen region and survival of Chinese patients with non-small cell lung carcinoma.Semantic proximity Read ↗

Single-nucleotide polymorphisms (5p15.33, 15q25.1, 6p22.1, 6q27 and 7p15.3) and lung cancer survival in the European Prospective Investigation into Cancer and Nutrition (EPIC).Semantic proximity Read ↗

Genetic variants in the plasminogen activator inhibitor-1 gene are associated with an increased risk of radiation pneumonitis in lung cancer patients.Semantic proximity Read ↗

The role of haplotype in 15q25.1 locus in lung cancer risk: results of scanning chromosome 15.Semantic proximity Read ↗

Plasminogen activator inhibitor-1 and susceptibility to lung cancer: a population genetics perspective.Semantic proximity Read ↗

A second genetic variant on chromosome 15q24-25.1 associates with lung cancer.Semantic proximity Read ↗

Plasminogen activator inhibitor-1 gene promoter 4G/5G polymorphism and risks of peripherally inserted central catheter-related venous thrombosis in patients with lung cancer: a prospective cohort study.Semantic proximity Read ↗

C-X-C motif receptor 2, endostatin and proteinase-activated receptor 1 polymorphisms as prognostic factors in NSCLC.Semantic proximity Read ↗

PLAUR polymorphisms and lung function in UK smokers.Semantic proximity Read ↗

A functional polymorphism on chromosome 15q25 associated with survival of early stage non-small-cell lung cancer.Semantic proximity Read ↗

Association of polymorphisms in the genes of the urokinase plasminogen activation system with susceptibility to and severity of non-small cell lung cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.