Article
Single-nucleotide polymorphisms (5p15.33, 15q25.1, 6p22.1, 6q27 and 7p15.3) and lung cancer survival in the European Prospective Investigation into Cancer and Nutrition (EPIC).
Mutagenesis - 1 Sept 2011
Xun Wei Wei, Brennan Paul, Tjonneland Anne, Vogel Ulla, Overvad Kim, Kaaks Rudolf, Canzian Federico, Boeing Heiner, Trichopoulou Antonia, Oustoglou Erifili, Giotaki Zoi, Johansson Mattias, Palli Domenico, Agnoli Claudia, Tumino Rosario, Sacerdote Carlotta, Panico Salvatore, Bueno-de-Mesquita H Bas, Peeters Petra H M, Lund Eiliv, Kumle Merethe, Rodríguez Laudina, Agudo Antonio, Sánchez Maria-José, Arriola Larraitz, Chirlaque María-Dolores, Barricarte Aurelio, Hallmans Göran, Rasmuson Torgny, Khaw Kay-Tee, Wareham Nicholas, Key Tim, Riboli Elio, Vineis Paolo
Abstract excerpt
The single-nucleotide polymorphisms (SNPs) rs402710 (5p15.33), rs16969968 and rs8034191 (15q25.1) have been consistently identified by genome-wide association studies (GWAS) as significant predictors of lung cancer risk, while rs4324798 (6p22.1) was previously found to influence survival time in small-cell lung cancer (SCLC) patients. Using the same population of one of the original GWAS, we investigated whether...