Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The influence of genetic variations in HHEX gene on insulin metabolism in the German MESYBEPO cohort.

Diabetes/metabolism research and reviews - 1 Feb 2009

Pivovarova Olga, Nikiforova Victoria J, Pfeiffer Andreas F H, Rudovich Natalia

Abstract excerpt

BACKGROUND: In the present study, we aimed to validate the type 2 diabetes (T2DM) susceptibility alleles identified in the first genome-wide association study in the hematopoietically expressed homeobox protein (HHEX) gene region (rs1111875 and rs7923837). Furthermore, we investigated quantitative metabolic risk phenotypes of these two variants for association with three key components of the insulin metabolism:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

Share to Genome, Human

Share to Germany

Share to Glucose Intolerance

Share to Glucose Tolerance Test

Share to Homeodomain Proteins

Share to Insulin

Share to Risk Assessment

Source

Identifiers

PMID: 19117022
DOI: 10.1002/dmrr.926

Genes

HHEX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The influence of genetic variations in HHEX gene on insulin metabolism in the German MESYBEPO cohort.PMID 19117022Read ↗

A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study.Semantic proximity Read ↗

Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function.Semantic proximity Read ↗

Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population.Semantic proximity Read ↗

HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort.Semantic proximity Read ↗

Hematopoietically-expressed homeobox gene three widely-evaluated polymorphisms and risk for diabetes: a meta-analysis.Semantic proximity Read ↗

Quantitative assessment of the influence of hematopoietically expressed homeobox variant (rs1111875) on type 2 diabetes risk.Semantic proximity Read ↗

Hematopoietically expressed homeobox (HHEX) gene polymorphism (rs5015480) is associated with increased risk of gestational diabetes mellitus.Semantic proximity Read ↗

Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.Semantic proximity Read ↗

Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.Semantic proximity Read ↗

Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function.Semantic proximity Read ↗

Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps.Semantic proximity Read ↗

Type 2 Diabetes Risk Allele UBE2E2 Is Associated With Decreased Glucose-Stimulated Insulin Release in Elderly Chinese Han Individuals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.