Article
HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort.
European journal of human genetics : EJHG - 1 May 2008
van Vliet-Ostaptchouk Jana V, Onland-Moret N Charlotte, van Haeften Timon W, Franke Lude, Elbers Clara C, Shiri-Sverdlov Ronit, van der Schouw Yvonne T, Hofker Marten H, Wijmenga Cisca
Abstract excerpt
Recently, the hematopoietically expressed homeobox (HHEX) gene, encoding a transcription factor, was identified in a large genome-wide scan in French individuals as a type 2 diabetes (T2D)-susceptibility locus. We aimed to check whether this finding could be replicated in a Dutch T2D cohort. Two common variants (rs7923837 and rs1111875) located near the HHEX gene were genotyped in 501 unrelated T2D patients and...
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