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A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study.

Diabetes - 1 Feb 2008

Staiger Harald, Stancáková Alena, Zilinskaite Jone, Vänttinen Markku, Hansen Torben, Marini Maria Adelaide, Hammarstedt Ann, Jansson Per-Anders, Sesti Giorgio, Smith Ulf, Pedersen Oluf, Laakso Markku, Stefan Norbert, Fritsche Andreas, Häring Hans-Ulrich

Abstract excerpt

OBJECTIVE: In recent genome-wide association studies, two single nucleotide polymorphisms (SNPs) near the HHEX locus were shown to be more frequent in type 2 diabetic patients than in control subjects. Based on HHEX's function during embryonic development of the ventral pancreas in mice, we investigated whether these SNPs affect beta-cell function in humans. RESEARCH DESIGN AND METHODS: A total of 854 nondiabetic...

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Identifiers

PMID: 18039816
DOI: 10.2337/db07-1254

Genes

HHEX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study.PMID 18039816Read ↗

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