Article
Velvet, a dominant Egfr mutation that causes wavy hair and defective eyelid development in mice.
Genetics - 1 Jan 2004
Du Xin, Tabeta Koichi, Hoebe Kasper, Liu Haiquan, Mann Navjiwan, Mudd Suzanne, Crozat Karine, Sovath Sosathya, Gong Xiaohua, Beutler Bruce
Abstract excerpt
In the course of a large-scale program of ENU mutagenesis, we isolated a dominant mutation, called Velvet. The mutation was found to be uniformly lethal to homozygotes, which do not survive E13.5. Mice heterozygous for the Velvet mutation are born with eyelids open and demonstrate a wavy coat and curly vibrissae. The mutation was mapped to the proximal end of chromosome 11 by genome-wide linkage analysis. On 249...
Topics
- Animals
- Base Sequence
- Chromosome Mapping
- DNA, Complementary
- ErbB Receptors
- Eyelids
- Female
- Genes, Dominant
- Genes, erbB-1
- Hair
- Heterozygote