Article
Singleton deletions throughout the genome increase risk of bipolar disorder.
Molecular psychiatry - 1 Apr 2009
Zhang D, Cheng L, Qian Y, Alliey-Rodriguez N, Kelsoe J R, Greenwood T, Nievergelt C, Barrett T B, McKinney R, Schork N, Smith E N, Bloss C, Nurnberger J, Edenberg H J, Foroud T, Sheftner W, Lawson W B, Nwulia E A, Hipolito M, Coryell W, Rice J, Byerley W, McMahon F, Schulze T G, Berrettini W, Potash J B, Belmonte P L, Zandi P P, McInnis M G, Zöllner S, Craig D, Szelinger S, Koller D, Christian S L, Liu C, Gershon E S
Abstract excerpt
An overall burden of rare structural genomic variants has not been reported in bipolar disorder (BD), although there have been reports of cases with microduplication and microdeletion. Here, we present a genome-wide copy number variant (CNV) survey of 1001 cases and 1034 controls using the Affymetrix single nucleotide polymorphism (SNP) 6.0 SNP and CNV platform. Singleton deletions (deletions that appear only...
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