Article
Identification of IL7RA risk alleles for rapid progression during HIV-1 infection: a comprehensive study in the GRIV cohort.
Current HIV research - 1 Mar 2012
Limou Sophie, Melica Giovanna, Coulonges Cédric, Lelièvre Jean-Daniel, Do Hervé, McGinn Steven, Gut Ivo G, Lévy Yves, Zagury Jean-François
Abstract excerpt
Interleukin 7 (IL7) is a critical factor for lymphocyte homeostasis. A dysfunction of the IL7/IL7R pathway has previously been described in HIV-1 infection, and promising results were observed in recent analyses of IL7 for therapeutic use in HIV infected individuals. However, further investigations are still warranted to understand the possible roles of this cytokine. Here, we explored whether the IL7 and IL7RA...
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