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Article

Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation.

Human molecular genetics - 15 Feb 2009

Cheung Ching-Lung, Chan Benjamin Y Y, Chan Vivian, Ikegawa Shiro, Kou Ikuyo, Ngai Heidi, Smith David, Luk Keith D K, Huang Qing-Yang, Mori Seijiro, Sham Pak-Chung, Kung Annie W C

Abstract excerpt

Bone mineral density (BMD) is one of the major determinants of risk for osteoporotic fracture. Multiple studies reveal that peak bone mass is under strong genetic influence. One of the major susceptibility loci for peak spine BMD has been mapped to chromosome 1q21-q23 in the Caucasian population. We have previously replicated this finding in Southern Chinese pedigrees and detected a maximum multipoint log of odds...

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Identifiers

PMID: 19064610
DOI: 10.1093/hmg/ddn397

Genes

PBX1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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