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Article

Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors

5 Feb 2008

Abstract excerpt

Multidrug resistance is often associated with the (over)expression of drug efflux transporters of the ATP-binding cassette (ABC) protein family. This minireview discusses the role of one selected ABC-transporter family member, the breast cancer resistance protein (BCRP/ABCG2), in the (pre)clinical efficacy of novel experimental anticancer drugs, in particular tyrosine kinase inhibitors.

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PMID: 18253130
DOI: 10.1038/sj.bjc.6604213

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