The Metastasis-Associated Gene <i>CD24</i> Is Regulated by Ral GTPase and Is a Mediator of Cell Proliferation and Survival in Human Cancer

Abstract excerpt

Ral GTPases are important mediators of transformation, tumorigenesis, and cancer progression. We recently identified the metastasis-associated protein CD24, a glycosyl phosphatidyl inositol-linked surface protein, as a downstream target of Ral signaling by profiling the expression of RalA/B-depleted bladder carcinoma cells. Because CD24 is highly expressed in bladder and many other tumor types, we sought to...

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