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Article

Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations.

Blood - 19 Feb 2009

Akagi Tadayuki, Shih Lee-Yung, Kato Motohiro, Kawamata Norihiko, Yamamoto Go, Sanada Masashi, Okamoto Ryoko, Miller Carl W, Liang Der-Cherng, Ogawa Seishi, Koeffler H Phillip

Abstract excerpt

Acute promyelocytic leukemia (APL) is a hematopoietic malignant disease characterized by the chromosomal translocation t(15;17), resulting in the formation of the PML-RARA gene. Here, 47 t(15;17) APL samples were analyzed with high-density single-nucleotide polymorphism microarray (50-K and 250-K SNP-chips) using the new algorithm AsCNAR (allele-specific copy-number analysis using anonymous references)....

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Share to Chromosomes, Human, Pair 15
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Promyelocytic, Acute

Share to Loss of Heterozygosity

Share to Oncogene Proteins, Fusion

Share to Translocation, Genetic

Source

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Identifiers

PMID: 19109227
DOI: 10.1182/blood-2007-12-130260
PMCID: PMC2647673

Genes

FLT3
PML
RARA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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