Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic anatomy of the specific reciprocal translocation t(15;17) in acute promyelocytic leukemia

13 Dec 2002

Abstract excerpt

The genomic breakpoints in the t(15;17)(q22;q21), associated with acute promyelocytic leukemia (APL), are known to occur within three different PML breakpoint cluster regions (bcr) on chromosome 15 and within RARA intron 2 on chromosome 17; however, the precise mechanism by which this translocation arises is unclear. To clarify this mechanism, we (i). assembled the sequence of RARA intron 2, (ii). amplified and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Advanced biosensing and bioanalysis techniques
Share to Retinoids in leukemia and cellular processes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12508246
DOI: 10.1002/gcc.10154

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic anatomy of the specific reciprocal translocation t(15;17) in acute promyelocytic leukemiaPMID 12508246Read ↗

Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locus.Semantic proximity Read ↗

Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia.Semantic proximity Read ↗

Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosisSemantic proximity Read ↗

RARA and PML gene rearrangements in acute promyelocytic leukemia with complex translocations and atypical features.Semantic proximity Read ↗

Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia.Semantic proximity Read ↗

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PMLSemantic proximity Read ↗

Breakpoint clusters of the <i>PML</i> gene in acute promyelocytic leukemia: Primary structure of the reciprocal products of the <i>PML‐RARA</i> gene in a patient with t(15;17)Semantic proximity Read ↗

Recurring chromosomal abnormalities in leukemia inPML-RARA transgenic mice parallel human acute promyelocytic leukemiaSemantic proximity Read ↗

Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations.Semantic proximity Read ↗

Pathogenesis, Diagnosis and Monitoring of Residual Disease in Acute Promyelocytic LeukaemiaSemantic proximity Read ↗

Optical Genome Mapping Reveals Complex and Cryptic Rearrangement Involving PML::RARA Fusion in Acute Promyelocytic LeukemiaSemantic proximity Read ↗

Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.