Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomewide array-based comparative genomic hybridization analysis of acute promyelocytic leukemia.

Genes, chromosomes & cancer - 1 Apr 2006

Karnan Sivasundaram, Tsuzuki Shinobu, Kiyoi Hitoshi, Tagawa Hiroyuki, Ueda Ryozo, Seto Masao, Naoe Tomoki

Abstract excerpt

Acute promyelocytic leukemia (APL) is typically associated with the t(15;17) that generates the PML-RARA fusion protein. Animal models have shown that although the fusion protein is necessary, it is insufficient for the development of APL, implying that additional mechanisms are responsible for full-blown leukemia. The mutation of specific genes has been implicated in leukemogenesis; however, alterations in gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Aberrations
Share to Chromosomes, Human, Pair 15

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 17

Share to fms-Like Tyrosine Kinase 3

Share to In Situ Hybridization, Fluorescence

Share to Leukemia, Promyelocytic, Acute

Share to Nucleic Acid Hybridization

Share to Translocation, Genetic

Source

Identifiers

PMID: 16419057
DOI: 10.1002/gcc.20309

Genes

PML
RARA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomewide array-based comparative genomic hybridization analysis of acute promyelocytic leukemia.PMID 16419057Read ↗

Single-nucleotide polymorphism array-based karyotyping of acute promyelocytic leukemia.Semantic proximity Read ↗

Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations.Semantic proximity Read ↗

Microarray, gene sequencing, and reverse transcriptase-polymerase chain reaction analyses of a cryptic PML-RARA translocation.Semantic proximity Read ↗

Optical Genome Mapping Reveals Complex and Cryptic Rearrangement Involving PML::RARA Fusion in Acute Promyelocytic LeukemiaSemantic proximity Read ↗

Genomic anatomy of the specific reciprocal translocation t(15;17) in acute promyelocytic leukemiaSemantic proximity Read ↗

Recurring chromosomal abnormalities in leukemia inPML-RARA transgenic mice parallel human acute promyelocytic leukemiaSemantic proximity Read ↗

RAR-alpha gene rearrangements as a genetic marker for diagnosis and monitoring in acute promyelocytic leukemiaSemantic proximity Read ↗

DNA profiling by arrayCGH in acute myeloid leukemia and myelodysplastic syndromes.Semantic proximity Read ↗

Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias.Semantic proximity Read ↗

Array comparative genomic hybridization analysis of adult acute leukemia patients.Semantic proximity Read ↗

Array comparative genomic hybridization (aCGH) analysis in Prader–Willi syndromeSemantic proximity Read ↗

Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.