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Article

Clinical impact of FLT3 mutation load in acute promyelocytic leukemia with t(15;17)/PML-RARA

22 Aug 2011

Abstract excerpt

BACKGROUND: Combined treatment with all-trans-retinoic acid and chemotherapy is extremely efficient in patients with acute promyelocytic leukemia with t(15;17)/PML-RARA, but up to 15% of patients relapse. DESIGN AND METHODS: To further clarify the prognostic impact of parameters such as FLT3 mutations, we comprehensively characterized the relation between genetic features and outcome in 147 patients (aged...

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Identifiers

PMID: 21859732
DOI: 10.3324/haematol.2011.049007

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