Evaluating alignment and variant-calling software for mutation identification in C. elegans by whole-genome sequencing.

Abstract excerpt

Whole-genome sequencing is a powerful tool for analyzing genetic variation on a global scale. One particularly useful application is the identification of mutations obtained by classical phenotypic screens in model species. Sequence data from the mutant strain is aligned to the reference genome, and then variants are called to generate a list of candidate alleles. A number of software pipelines for mutation...

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