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Caenorhabditis elegans mutant allele identification by whole-genome sequencing.

Nature methods - 1 Oct 2008

Sarin Sumeet, Prabhu Snehit, O'Meara M Maggie, Pe'er Itsik, Hobert Oliver

Abstract excerpt

Identification of the molecular lesion in Caenorhabditis elegans mutants isolated through forward genetic screens usually involves time-consuming genetic mapping. We used Illumina deep sequencing technology to sequence a complete, mutant C. elegans genome and thus pinpointed a single-nucleotide mutation in the genome that affects a neuronal cell fate decision. This constitutes a proof-of-principle for using...

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PMID: 18677319
DOI: 10.1038/nmeth.1249
PMCID: PMC2574580

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