Article
Testis-specific peroxiredoxin 4 variant is not absolutely required for spermatogenesis and fertility in mice.
Scientific reports - 21 Oct 2020
Homma Takujiro, Kurahashi Toshihiro, Ishii Naoki, Shirasawa Nobuyuki, Fujii Junichi
Abstract excerpt
PRDX4, a member of peroxiredoxin family, is largely concentrated in the endoplasmic reticulum (ER) and plays a pivotal role in the redox relay during oxidative protein folding as well as in peroxidase reactions. A testis-specific PRDX4 variant transcript (PRDX4t) lacks the conventional exon 1, which encodes the signal peptide that is required for entry into the ER lumen, but instead carries alternative exon 1,...
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