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The testes‐specific bZip type transcription factor <i>Tisp40</i> plays a role in ER stress responses and chromatin packaging during spermiogenesis

31 Aug 2006

Abstract excerpt

We previously reported that the spermatid-specific transcription factor Tisp40 functions through UPRE and CRE. To investigate Tisp40 function in vivo, we generated TISP40(-/-) mice. TISP40(-/-) mice were born at expected ratios, were healthy, and mutant males bred normally. However, the ER stress-response protein Grp78/BiP accumulated in the TISP40(-/-) testis and RAMP4 (Ribosome-associated membrane protein 4)...

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PMID: 16999736
DOI: 10.1111/j.1365-2443.2006.01013.x

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