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Article

Increased N-terminal cleavage of alpha-2-antiplasmin in patients with liver cirrhosis.

Journal of thrombosis and haemostasis : JTH - 1 Nov 2013

Uitte de Willige S, Malfliet J J M C, Janssen H L A, Leebeek F W G, Rijken D C

Abstract excerpt

BACKGROUND: The activity of alpha-2-antiplasmin (α2AP), the main fibrinolytic inhibitor, is modified by N- and C-terminal proteolytic cleavages. C-terminal cleavage converts plasminogen-binding α2AP (PB-α2AP) into a non-plasminogen-binding derivative. N-terminal cleavage by antiplasmin-cleaving enzyme (APCE), a soluble, circulating derivative of fibroblast activation protein (FAP), turns native Met-α2AP into...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24034420
DOI: 10.1111/jth.12396

Genes

FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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