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Article

Evaluation of angiotensinogen c.1-44G>A and p.M268T variants as risk factors for fibrosis progression in chronic hepatitis C and liver diseases of various etiologies.

Genetic testing and molecular biomarkers - 1 Jun 2009

Halangk Juliane, Berg Thomas, Neumann Konrad, Sarrazin Christoph, Hinrichsen Holger, Fitz Carolin, Puhl Gero, Mueller Tobias, Neuhaus Peter, Wiedenmann Bertram, Witt Heiko

Abstract excerpt

BACKGROUND: Hepatic stellate cells express all components of the renin-angiotensinogen (AGT) system and secrete active angiotensin II. Animal studies provided evidence that angiotensin II stimulates the accumulation of extracellular matrix by enhancing transforming growth factor beta1 production. A functional genetic alteration in the human AGT promoter (c.1-44G>A) has been linked to accelerated progression of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19473084
DOI: 10.1089/gtmb.2008.0135

Genes

AGT

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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