A DDX5 S480A polymorphism is associated with increased transcription of fibrogenic genes in hepatic stellate cells.

doi:10.1074/jbc.M109.035295

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Article

A DDX5 S480A polymorphism is associated with increased transcription of fibrogenic genes in hepatic stellate cells.

The Journal of biological chemistry - 19 Feb 2010

Guo Jinsheng, Hong Feng, Loke Johnny, Yea Steven, Lim Chooi Ling, Lee Ursula, Mann Derek A, Walsh Martin J, Sninsky John J, Friedman Scott L

Abstract excerpt

We recently identified a missense single nucleotide polymorphism (SNP) in DDX5 (rs1140409, p.S480A) that enhances the risk of developing cirrhosis. DDX5 is an ATP-dependent RNA helicase and transcriptional modulator. We hypothesized that the activity of DDX5 in regulating fibrogenic gene transcri...

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Identifiers

PMID: 20022962
DOI: 10.1074/jbc.M109.035295
PMCID: PMC2820771

Genes

DDX5
HDAC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20022962-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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