A DDX5 S480A polymorphism is associated with increased transcription of fibrogenic genes in hepatic stellate cells.

doi:10.1074/jbc.M109.035295

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Article

A DDX5 S480A polymorphism is associated with increased transcription of fibrogenic genes in hepatic stellate cells.

The Journal of biological chemistry - 19 Feb 2010

Guo Jinsheng, Hong Feng, Loke Johnny, Yea Steven, Lim Chooi Ling, Lee Ursula, Mann Derek A, Walsh Martin J, Sninsky John J, Friedman Scott L

Abstract excerpt

We recently identified a missense single nucleotide polymorphism (SNP) in DDX5 (rs1140409, p.S480A) that enhances the risk of developing cirrhosis. DDX5 is an ATP-dependent RNA helicase and transcriptional modulator. We hypothesized that the activity of DDX5 in regulating fibrogenic gene transcription in hepatic stellate cells (HSCs) is altered by the S480A SNP. To test this, we employed two approaches: 1)...

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Identifiers

PMID: 20022962
DOI: 10.1074/jbc.M109.035295
PMCID: PMC2820771

Genes

DDX5
HDAC1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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