Article

Analyses of DNA methylation involved in the activation of nuclear karyopherin alpha 2 leading to the progression and prognostic significance across human breast cancer

2020-02-26

Abstract excerpt

<h4>Background: </h4> Karyopherin alpha 2 (KPNA2) is a nuclear import factor that plays a crucial role in nucleocytoplasmic transport, as well as cell proliferation, migration and invasion in several cancers. However, the roles of KPNA2 in breast cancer as well as the underlying molecular mechanisms have not been elucidated. <h4>Methods:</h4> To evaluate gene expression alterations during breast carcinogenesis, KP...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4b61c142-47fe-538f-a13c-6e6fdbc612e5
DOI: 10.21203/rs.2.24589/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Analyses of DNA methylation involved in the activation of nuclear karyopherin alpha 2 leading to the progression and prognostic significance across human breast cancerDOI 10.21203/rs.2.24589/v1Read

Oncogenic role of karyopherin α2 (KPNA2) in human tumors: A pan-cancer analysisSemantic proximity Read

Comprehensive Analysis of the Expression, Prognosis and Immune Infiltration of KPNA Family in Hepatocellular CarcinomaSemantic proximity Read

The role of <i>KPNA2</i> mutations in breast cancer prognosis: A survey of publicly available databasesSemantic proximity Read

IRF2 Destabilizes Oncogenic KPNA2 to Modulate the Tumorigenesis of Osteosarcoma via Regulating NF-κB/p65Semantic proximity Read

Integrative Bioinformatics Analysis of KPNA2 in Six Major Human CancersSemantic proximity Read

KPNA4 Serves as A Biomarker For Pancreatic Adnenocarcinoma KPNA4 Serves as A Promising Diagnostic and Prognostic Biomarker For Human Pancreatic AdenocarcinomaSemantic proximity Read

Molecular Profiling of Multiple Human Cancers Defines an Inflammatory Cancer-Associated Molecular Pattern and Uncovers KPNA2 as a Uniform Poor Prognostic Cancer MarkerSemantic proximity Read

Evaluation of the role of KPNA2 mutations in breast cancer prognosis using bioinformatics datasets.Semantic proximity Read

MicroRNA-567 dysregulation contributes to carcinogenesis of breast cancer, targeting tumor cell proliferation, and migration.Semantic proximity Read

Nuclear transport receptor karyopherin-α2 promotes malignant breast cancer phenotypes in vitro.Semantic proximity Read

Depletion of nuclear import protein karyopherin alpha 7 (KPNA7) induces mitotic defects and deformation of nuclei in cancer cellsSemantic proximity Read

Molecular Profiling of Laser-Microdissected Matched Tumor and Normal Breast Tissue Identifies Karyopherin α2 as a Potential Novel Prognostic Marker in Breast CancerSemantic proximity Read