Article
Skin metabolism of aminophenols: human keratinocytes as a suitable in vitro model to qualitatively predict the dermal transformation of 4-amino-2-hydroxytoluene in vivo.
Toxicology and applied pharmacology - 15 Feb 2009
Goebel C, Hewitt N J, Kunze G, Wenker M, Hein D W, Beck H, Skare J
Abstract excerpt
4-Amino-2-hydroxytolune (AHT) is an aromatic amine ingredient in oxidative hair colouring products. As skin contact occurs during hair dyeing, characterisation of dermal metabolism is important for the safety assessment of this chemical class. We have compared the metabolism of AHT in the human keratinocyte cell line HaCaT with that observed ex-vivo in human skin and in vivo (topical application versus oral...
Topics
- 4-Aminobenzoic Acid
- Adult
- Aniline Compounds
- Animals
- Arylamine N-Acetyltransferase
- Cells, Cultured
- Cresols
- Female
- Genotype
- Humans
- Isoenzymes
- Keratinocytes
- Middle Aged
- Molecular Structure