Article
Urinary acetylated metabolites and N-acetyltransferase-2 genotype in human subjects treated with a para-phenylenediamine-containing oxidative hair dye.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Nov 2004
Nohynek Gerhard J, Skare Julie A, Meuling Wim J A, Hein David W, De Bie Albert Th H J, Toutain Herve
Abstract excerpt
In the organism of mammals, important detoxification pathways of arylamines are catalysed by N-acetyltransferase 2 (NAT2). A recent case-control epidemiology study suggested that human NAT2 slow acetylators exposed to oxidative hair dyes may be at greater risk to develop bladder cancer. We therefore profiled urinary [(14)C]-metabolites and NAT2 genotype in eight human subjects following treatment with a...
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