Metabolic kinetics of p-aminobenzoic acid in rabbits.

doi:10.1002/(sici)1099-081x(199907)20:5<263::aid-bdd184>3.0.co;2-g

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Article

Metabolic kinetics of p-aminobenzoic acid in rabbits.

Biopharmaceutics & drug disposition - 1 Jul 1999

Song D J, Ho Y, Hsu K Y

Abstract excerpt

The metabolic kinetics of p-aminobenzoic acid (PABA) in rabbits was studied. PABA is predominantly metabolized by acetylation and glycine conjugation to form p-acetamidobenzoic acid (PAABA), p-aminohippuric acid (PAHA), and p-acetamidohippuric acid (PAAHA). After PABA IV administration (20 mg/kg) to rapid (n=16) and slow (n=8) acetylation rabbits, PABA was eliminated rapidly. The half-lives of PABA were...

Topics

4-Aminobenzoic Acid
Acetylation
Animals
Male
Phenotype
Rabbits

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