Article
Low N-acetylating capacity in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis.
Experimental dermatology - 1 Oct 1995
Dietrich A, Kawakubo Y, Rzany B, Mockenhaupt M, Simon J C, Schöpf E
Abstract excerpt
Low constitutive N-acetylating capacity has been implicated as a predisposing factor for the development of adverse reactions to certain drugs. This prompted us to investigate whether the N-acetylating capacity of patients with serious cutaneous adverse reactions, i.e., Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) differed from that of healthy control subjects. N-acetylating activity was...
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